Identification and validation of DNA methylation markers to predict axillary lymph node metastasis of breast cancer.

BackgroundAxillary lymph node metastasis (ALNM) is one of the most important prognostic factors for breast cancer patients, and DNA methylation is involved in ALNM of breast cancer.However, the methylation profile of breast cancer ALNM remains unknown.MethodsBreast cancer tissues were collected from patients with and without ALNM.We investigated th

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Premenstrual Exacerbation of Life-Threatening Asthma: Effect of Gonadotrophin Releasing Hormone Analogue Therapy

Variability in the severity of asthma during various phases of the menstrual cycle has been frequently suspected.However, the hormonal changes that might affect mediators of bronchospasm have yet to be elucidated.The case of a 41-year-old woman suffering from longstanding asthma with life-threatening exacerbations is reported.The patient was treate

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